OAB Research: A Roundup of the Latest OAB Research News

The Latest News About OAB Research

OAB ResearchAhhh. 2018 – the start of a new year. And with a new year, the fresh promise of new research that could possibly change everyone’s lives who is living with a chronic disease.

So, what happened last year, for those of people living with overactive bladder (OAB)? What is on the forefront? What can you expect, coming down the pike?

Well, today, I pulled together some of the latest research.

Clinical Trials… and Bitcoin?

By now, we’ve all heard of Bitcoin (although few of us probably have an actual grasp on what the cryptocurrency actually is, am I right?)

Well, at the end of 2017, the patented Bladder RE-EXPANSION Technique to patients, the clinical trial has begun to accept the Bitcoin as cryptocurrency donations via this address: 1MYQWHJFYHDsUkSvsRVGjHudJdniXMye5F. Depending on how much is donated, the trial can be performed at a well-known, top ranked hospital, or a private clinical research facility.

The device, created by Dr. Justin Mandel, DOM AP LAC, states that by increasing abdominopelvic flexibility, which then decreases urinary symptoms. It is thought that it “reexpands” the space surrounding the bladder, “which allows it to normally refill with urine without experiencing increased urinary symptoms.”

So, a research study relying on Bitcoin is in the works!

Incontinence Drug May Help Sleep as Well

For those of you prescribed Toviaz (fesoterodine), here’s some interesting news!

New research shows that this antimuscarinic agent, which has long been prescribed to treat incontinence associated with OAB, may also improve sleep as well!


Leslee L. Subak, MD, professor and chair of obstetrics and gynecology at Stanford University School of Medicine states that fesoterodine works by inhibiting the activity of the muscarinic acetylcholine receptors. She states that these agents “block those receptors so the bladder remains calmer.”

The study used 270 women in the placebo group and 277 women in the treatment group, with an average age of 56. The study researched incontinence as well as sleepiness. The two groups had improvements in incontinence. There was also an improvement in sleep quality, but it did not reduce daytime sleepiness.

Dr. Subak notes, “Antimuscarinic and anticholinergic medications can produce somnolence.” This is because it has a sedating effect.

Don’t call up your physician to ask for a medication change just yet! The study did have some flaws – it did not assess for underlying sleep issues, such as sleep apnea.

Douglas Kirsch, MD, medical director of Carolinas HealthCare Sleep Medicine, states, “As well, there was not an objective measurement of sleep, such as actigraphy, which could have been helpful in demonstrating improvements in sleep quality.”

UTI Test Strips for Home Use

A bit of exciting news for everyone! How many times have you thought you had a urinary tract infection (UTI) due to OAB, made an appointment with your physician, and ponied up that hefty copay… just to find out that you don’t, in fact, have a UTI?

The Food and Drug Administration (FDA) has just approved Innovus UriVarx Urinary Tract Infection testing strips specifically for people with OAB and urinary incontinence.

UriVarx UTI strips can detect the presence of leukocytes and nitrites in urine when used at home and the results are quick – they are shown on the strip within two minutes.

The strips will launch this quarter (early January 2018) and will be available over-the-counter, without a physician’s prescription.

Sacral Neuromodulation System… Say What?

An US-based company, Axonics Modulation Technologies, Inc, recently announced that it received marketing approval in Australia for a fully rechargeable device that treats overactive bladder, fecal incontinence, urinary retention – the Sacral Neuromodulation (r-SNM) System.

According to Business Wire, “The Axonics r-SNM system includes a miniaturized rechargeable implantable stimulator qualified to function at least 15 years, a charging system optimized for reduced charge time without overheating, a patient-friendly remote control and an intuitive clinician programmer that facilitates the lead placement procedure and programming.”

In 2016, the Food and Drug Administration Axonics an Investigational Device Exemption to conduct a pivotal study to gain approval of their device in the US.

Apparently, we’ll find out more on how it functions in the coming months.

The Bottom Line…

The interesting thing about medicine is that it is always changing. There are new devices that are meant to manage our conditions and make our lives better. We’re finding ways to manage (and treat, and prevent!) our conditions. We’re even finding new indications for drugs that have been on the market for years!

Next page: Read about 2017’s OAB research roundup. 

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